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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 183097, 6 pages
Research Article

Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, 1000 Ljubljana, Slovenia
2Department of Environmental Sciences, Jožef Stefan Institute, Jamova c. 39, 1000 Ljubljana, Slovenia
3Faculty of Electrical Engeneering, University of Ljubljana, Tržaška 25, 1000 Ljubljana, Slovenia

Received 30 December 2009; Accepted 9 March 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Jakob Kljun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Novel ruthenium(III) complexes with histamine (1a) and (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.