Research Article
Synthesis and Biological Evaluation of New CRH Analogues
Table 3
Binding affinities of h/r-CRH analogues.
| | Analogues | Binding IC50 (nM) |
| | h/r-CRH | 17.3 | 1 | [D-Phe12, Aib14]CRH | 226 | 2 | [D-Phe12, Aib15]CRH | 8.4 | 3 | [D-Phe12, Cys(Et)21]CRH | 28.5 | 4 | [D-Phe12, Cys(Pr)38]CRH | 35 | 5 | [D-Phe12, Cys(Et)21, Cys(Pr)38]CRH | 7.0 | 6 | [D-Phe12, Cys(Pr)21, Cys(Et)38]CRH | 3.4 | 7 | [D-Phe12, Cys(Pr)21, Cys(Pr)38]CRH | 17.3 |
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values given are averages from 3 experiments performed in duplicates.
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