Research Article
Synthesis and Biological Evaluation of New CRH Analogues
Table 4
Biological activity of h/r-CRH analogues.
| | Analogues | Biological activity |
| | h/r-CRH | 100% activity (Full agonist) | 1 | [D-Phe12, Aib14]CRH | (Partial Agonist, 60% Response max/CRH) | 2 | [D-Phe12, Aib15]CRH | (Partial Agonist, 60% Response max/CRH) | 3 | [D-Phe12, Cys(Et)21]CRH | (Full Agonist, 110% Response max/CRH) | 4 | [D-Phe12, Cys(Pr)38]CRH | (Partial Agonist, 60% Response max/CRH) | 5 | [D-Phe12,Cys(Et)21, Cys(Pr)38]CRH | (Partial Agonist, 70% Response max/CRH) | 6 | [D-Phe12, Cys(Pr)21, Cys(Et)38]CRH | (Partial Agonist, 60% Response max/CRH) | 7 | [D-Phe12, Cys(Pr)21, Cys(Pr)38]CRH | (Partial Agonist, 80% Response max/CRH) |
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