The <svg     style="vertical-align:-0.0pt;width:14.4875px;" id="M1" height="15.025" version="1.1" viewBox="0 0 14.4875 15.025" width="14.4875"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><path id="x394" d="M600 0h-557v24l268 633l28 8l261 -641v-24zM497 50l-194 489l-196 -489h390z" /></g>

		
	
</svg>33-35 Mutant <svg     style="vertical-align:-0.216pt;width:12.8625px;" id="M2" height="10.4375" version="1.1" viewBox="0 0 12.8625 10.4375" width="12.8625"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FC" d="M545 106q-67 -118 -134 -118q-24 0 -40 37.5t-30 129.5h-2q-47 -72 -103 -119.5t-108 -47.5q-47 0 -76 45.5t-29 119.5q0 113 85 204t174 91q47 0 70 -33.5t43 -119.5h3q32 47 80 140l55 13l10 -9q-47 -80 -138 -201q17 -99 27.5 -136t22.5 -37q23 0 69 61zM333 204
q-14 98 -31 149.5t-50 51.5q-49 0 -94 -70t-45 -164q0 -55 15.5 -86t40.5 -31q70 0 164 150z" /></g>

		
	
</svg>-Domain Containing <svg     style="vertical-align:-4.698pt;width:13.15px;" id="M3" height="21.9375" version="1.1" viewBox="0 0 13.15 21.9375" width="13.15"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
t-62 25.5q-24 0 -43.5 -9t-35 -29.5t-27 -44t-22.5 -63t-19.5 -75.5t-18.5 -91q-57 -294 -68 -380q-26 -190 -35 -200q-26 -31 -97 -37l-4 26q19 9 48 170l77 413q23 121 52.5 187.5t83.5 114.5q70 62 148 62q51 0 88.5 -34t37.5 -91z" /></g>

		
	
</svg>-Domain-Like <svg     style="vertical-align:-4.49648pt;width:47.662498px;" id="M4" height="20.625" version="1.1" viewBox="0 0 47.662498 20.625" width="47.662498"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><path id="x4D" d="M861 0h-263v28q61 5 73 22t12 97l-4 408h-4l-244 -548h-20l-224 534h-2l-15 -285q-5 -98 -3 -166q1 -34 19.5 -45t72.5 -17v-28h-233v28q45 5 62.5 17t22.5 43q11 65 19 183l14 208q3 36 3.5 55t-2.5 37.5t-6.5 25t-16.5 13t-25.5 8t-39.5 4.5v28h164l228 -501l232 501
h170v-28q-68 -6 -81 -21.5t-11 -91.5l9 -362q2 -80 15 -97t78 -22v-28z" /></g>

			<g transform="matrix(.016,-0,0,-.016,20.038,20.35)"><path id="x1D7D1" d="M58 524l-21 12q80 152 229 152q73 0 119 -41q45 -41 45 -96q0 -40 -21.5 -74.5t-62.5 -52.5q57 -20 89.5 -68.5t32.5 -109.5q0 -110 -86 -185t-214 -75q-69 0 -110.5 24.5t-41.5 65.5q0 26 18.5 43t46.5 17q45 0 96 -57q39 -43 79 -43q45 0 71.5 34t26.5 88q0 75 -49 121
q-25 23 -56 39q-34 17 -97 38v17q69 21 100 53t31 78q0 103 -99 103q-40 0 -69.5 -19t-56.5 -64z" /></g>

			<g transform="matrix(.022,-0,0,-.022,28.5,14.975)"><path id="x53" d="M409 504l-29 -5q-16 60 -44.5 96t-86.5 36q-54 0 -82.5 -32t-28.5 -77q0 -51 30.5 -82.5t96.5 -65.5l35.5 -18t33 -19.5t33.5 -23.5l27 -25.5t24.5 -32t13.5 -36.5t6 -45q0 -80 -62 -134.5t-160 -54.5q-47 0 -98 15q-22 7 -50 21q-8 23 -27 155l30 7q7 -27 18 -52
t30 -51.5t49 -42.5t67 -16q56 0 88 32.5t32 87.5q0 51 -31.5 82t-98.5 67q-80 44 -110 73q-55 53 -55 124q0 75 56 126.5t150 51.5q53 0 126 -23z" /></g>

			<g transform="matrix(.016,-0,0,-.016,39.125,20.35)"><path id="x1D7D7" d="M31 -13v26q107 22 171.5 85t96.5 175q-37 -19 -88 -19q-83 0 -134 55t-51 150q0 98 61 163q61 66 154 66q105 0 168 -80q64 -79 64 -214q0 -183 -145 -297q-68 -53 -127 -75q-54 -21 -170 -35zM317 414v47q0 118 -25 167q-16 33 -54 33q-34 0 -47 -31q-13 -29 -13 -117
q0 -116 19.5 -165t65.5 -49q27 0 41 9q3 1 5 20q8 34 8 86z" /></g>

		
	
</svg> Cluster Exhibits the Function of <svg     style="vertical-align:-0.216pt;width:12.8625px;" id="M5" height="10.4375" version="1.1" viewBox="0 0 12.8625 10.4375" width="12.8625"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><use xlink:href="#x1D6FC"/></g>

		
	
</svg>-Domain with <svg     style="vertical-align:-4.32007pt;width:55.5px;" id="M6" height="20.4125" version="1.1" viewBox="0 0 55.5 20.4125" width="55.5"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><use xlink:href="#x4D"/></g>

			<g transform="matrix(.016,-0,0,-.016,20.038,20.35)"><path id="x1D7D2" d="M476 255v-111h-64v-144h-145v144h-248v113l313 431h80v-433h64zM60 255h208v294z" /></g>

			<g transform="matrix(.022,-0,0,-.022,28.5,14.975)"><use xlink:href="#x53"/></g>

			<g transform="matrix(.016,-0,0,-.016,39.125,20.35)"><path id="x1D7CF" d="M441 24v-24h-373v24q75 2 96 20q22 19 22 85v378q0 70 -36 70q-26 0 -65 -16l-20 -8v26l251 109h18v-570q0 -57 19 -75q19 -17 88 -19z" /></g><g transform="matrix(.016,-0,0,-.016,46.971,20.35)"><use xlink:href="#x1D7CF"/></g>

		
	
</svg> Cluster in Human Growth Inhibitory Factor

<table>Amino acid sequence alignments of sheep MT3, human MT3, and its mutants.</table>

Bioinorganic Chemistry and Applications

fig1

Figure 1

Figure 1: The <svg     style="vertical-align:-0.0pt;width:14.4875px;" id="M1" height="15.025" version="1.1" viewBox="0 0 14.4875 15.025" width="14.4875"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><path id="x394" d="M600 0h-557v24l268 633l28 8l261 -641v-24zM497 50l-194 489l-196 -489h390z" /></g>

		
	
</svg>33-35 Mutant <svg     style="vertical-align:-0.216pt;width:12.8625px;" id="M2" height="10.4375" version="1.1" viewBox="0 0 12.8625 10.4375" width="12.8625"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><path id="x1D6FC" d="M545 106q-67 -118 -134 -118q-24 0 -40 37.5t-30 129.5h-2q-47 -72 -103 -119.5t-108 -47.5q-47 0 -76 45.5t-29 119.5q0 113 85 204t174 91q47 0 70 -33.5t43 -119.5h3q32 47 80 140l55 13l10 -9q-47 -80 -138 -201q17 -99 27.5 -136t22.5 -37q23 0 69 61zM333 204
q-14 98 -31 149.5t-50 51.5q-49 0 -94 -70t-45 -164q0 -55 15.5 -86t40.5 -31q70 0 164 150z" /></g>

		
	
</svg>-Domain Containing <svg     style="vertical-align:-4.698pt;width:13.15px;" id="M3" height="21.9375" version="1.1" viewBox="0 0 13.15 21.9375" width="13.15"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,16.025)"><path id="x1D6FD" d="M558 587q0 -32 -14 -61t-40 -53.5t-48.5 -41t-54.5 -36.5q144 -51 144 -174q0 -55 -43.5 -108t-104.5 -87q-77 -42 -131 -42q-31 0 -54 20t-31 47l11 18q48 -29 108 -29q79 0 119.5 43t40.5 109t-44.5 107.5t-119.5 50.5l22 47q34 1 65 21q96 61 96 157q0 42 -24 67.5
t-62 25.5q-24 0 -43.5 -9t-35 -29.5t-27 -44t-22.5 -63t-19.5 -75.5t-18.5 -91q-57 -294 -68 -380q-26 -190 -35 -200q-26 -31 -97 -37l-4 26q19 9 48 170l77 413q23 121 52.5 187.5t83.5 114.5q70 62 148 62q51 0 88.5 -34t37.5 -91z" /></g>

		
	
</svg>-Domain-Like <svg     style="vertical-align:-4.49648pt;width:47.662498px;" id="M4" height="20.625" version="1.1" viewBox="0 0 47.662498 20.625" width="47.662498"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><path id="x4D" d="M861 0h-263v28q61 5 73 22t12 97l-4 408h-4l-244 -548h-20l-224 534h-2l-15 -285q-5 -98 -3 -166q1 -34 19.5 -45t72.5 -17v-28h-233v28q45 5 62.5 17t22.5 43q11 65 19 183l14 208q3 36 3.5 55t-2.5 37.5t-6.5 25t-16.5 13t-25.5 8t-39.5 4.5v28h164l228 -501l232 501
h170v-28q-68 -6 -81 -21.5t-11 -91.5l9 -362q2 -80 15 -97t78 -22v-28z" /></g>

			<g transform="matrix(.016,-0,0,-.016,20.038,20.35)"><path id="x1D7D1" d="M58 524l-21 12q80 152 229 152q73 0 119 -41q45 -41 45 -96q0 -40 -21.5 -74.5t-62.5 -52.5q57 -20 89.5 -68.5t32.5 -109.5q0 -110 -86 -185t-214 -75q-69 0 -110.5 24.5t-41.5 65.5q0 26 18.5 43t46.5 17q45 0 96 -57q39 -43 79 -43q45 0 71.5 34t26.5 88q0 75 -49 121
q-25 23 -56 39q-34 17 -97 38v17q69 21 100 53t31 78q0 103 -99 103q-40 0 -69.5 -19t-56.5 -64z" /></g>

			<g transform="matrix(.022,-0,0,-.022,28.5,14.975)"><path id="x53" d="M409 504l-29 -5q-16 60 -44.5 96t-86.5 36q-54 0 -82.5 -32t-28.5 -77q0 -51 30.5 -82.5t96.5 -65.5l35.5 -18t33 -19.5t33.5 -23.5l27 -25.5t24.5 -32t13.5 -36.5t6 -45q0 -80 -62 -134.5t-160 -54.5q-47 0 -98 15q-22 7 -50 21q-8 23 -27 155l30 7q7 -27 18 -52
t30 -51.5t49 -42.5t67 -16q56 0 88 32.5t32 87.5q0 51 -31.5 82t-98.5 67q-80 44 -110 73q-55 53 -55 124q0 75 56 126.5t150 51.5q53 0 126 -23z" /></g>

			<g transform="matrix(.016,-0,0,-.016,39.125,20.35)"><path id="x1D7D7" d="M31 -13v26q107 22 171.5 85t96.5 175q-37 -19 -88 -19q-83 0 -134 55t-51 150q0 98 61 163q61 66 154 66q105 0 168 -80q64 -79 64 -214q0 -183 -145 -297q-68 -53 -127 -75q-54 -21 -170 -35zM317 414v47q0 118 -25 167q-16 33 -54 33q-34 0 -47 -31q-13 -29 -13 -117
q0 -116 19.5 -165t65.5 -49q27 0 41 9q3 1 5 20q8 34 8 86z" /></g>

		
	
</svg> Cluster Exhibits the Function of <svg     style="vertical-align:-0.216pt;width:12.8625px;" id="M5" height="10.4375" version="1.1" viewBox="0 0 12.8625 10.4375" width="12.8625"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,10.1)"><use xlink:href="#x1D6FC"/></g>

		
	
</svg>-Domain with <svg     style="vertical-align:-4.32007pt;width:55.5px;" id="M6" height="20.4125" version="1.1" viewBox="0 0 55.5 20.4125" width="55.5"  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,-0,0,-.022,.062,14.975)"><use xlink:href="#x4D"/></g>

			<g transform="matrix(.016,-0,0,-.016,20.038,20.35)"><path id="x1D7D2" d="M476 255v-111h-64v-144h-145v144h-248v113l313 431h80v-433h64zM60 255h208v294z" /></g>

			<g transform="matrix(.022,-0,0,-.022,28.5,14.975)"><use xlink:href="#x53"/></g>

			<g transform="matrix(.016,-0,0,-.016,39.125,20.35)"><path id="x1D7CF" d="M441 24v-24h-373v24q75 2 96 20q22 19 22 85v378q0 70 -36 70q-26 0 -65 -16l-20 -8v26l251 109h18v-570q0 -57 19 -75q19 -17 88 -19z" /></g><g transform="matrix(.016,-0,0,-.016,46.971,20.35)"><use xlink:href="#x1D7CF"/></g>

		
	
</svg> Cluster in Human Growth Inhibitory Factor 

Figure 1 | The 
	
		
			

		
	
33-35 Mutant 
	
		
			

		
	
-Domain Containing 
	
		
			

		
	
-Domain-Like 
	
		
			

			

			

			

		
	
 Cluster Exhibits the Function of 
	
		
			

		
	
-Domain with 
	
		
			

			

			

			

		
	
 Cluster in Human Growth Inhibitory Factor 

Bioinorganic Chemistry and Applications

The 33-35 Mutant -Domain Containing -Domain-Like Cluster Exhibits the Function of -Domain with Cluster in Human Growth Inhibitory Factor

Figure 1