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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 731202, 8 pages
http://dx.doi.org/10.1155/2010/731202
Research Article

Structurally Diverse Metal Coordination Compounds, Bearing Imidodiphosphinate and Diphosphinoamine Ligands, as Potential Inhibitors of the Platelet Activating Factor

1Biochemistry Laboratory, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece
2Inorganic Chemistry Laboratory, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece

Received 15 March 2010; Accepted 3 May 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Alexandros B. Tsoupras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metal complexes bearing dichalcogenated imidodiphosphinate ligands (E = O, S, Se, Te), which act as (E,E) chelates, exhibit a remarkable variety of three-dimensional structures. A series of such complexes, namely, square-planar , tetrahedral , E = O, S, and octahedral , were tested as potential inhibitors of either the platelet activating factor (PAF)- or thrombin-induced aggregation in both washed rabbit platelets and rabbit platelet rich plasma. For comparison, square-planar , X = Cl, Br, the corresponding metal salts of all complexes and the ligand were also investigated. showed the highest anti-PAF activity but did not inhibit the thrombin-related pathway, whereas , with also a significant PAF inhibitory effect, exhibited the highest thrombin-related inhibition. and inhibited moderately both PAF and thrombin, being more effective towards PAF. This work shows that the PAF-inhibitory action depends on the structure of the complexes studied, with the bulkier being the most efficient and selective inhibitor.