Bioinorganic Chemistry and Applications
Volume 2011 (2011), Article ID 306465, 6 pages
http://dx.doi.org/10.1155/2011/306465
Research Article
Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity
Department of Chemistry, University of Basel, Spitalstrasse 51, Basel 4056, Switzerland
Received 22 December 2010; Accepted 21 January 2011
Academic Editor: Zheng Dong
Copyright © 2011 Narasimha Rao Uda and Marc Creus. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- WHO, Antimicrobial Resistance, World Health Organisation, 2002.
- S. B. Levy, “The challenge of antibiotic resistance,” Scientific American, vol. 278, no. 3, pp. 46–53, 1998. View at Google Scholar · View at Scopus
- D. Gillner, N. Armoush, R. C. Holz, and D. P. Becker, “Inhibitors of bacterial N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity,” Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 22, pp. 6350–6352, 2009. View at Publisher · View at Google Scholar · View at Scopus
- T. L. Born, R. Zheng, and J. S. Blanchard, “Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism,” Biochemistry, vol. 37, no. 29, pp. 10478–10487, 1998. View at Publisher · View at Google Scholar · View at Scopus
- G. Scapin and J. S. Blanchard, “Enzymology of bacterial lysine biosynthesis,” Advances in Enzymology and Related Areas of Molecular Biology, vol. 72, pp. 279–324, 1998. View at Google Scholar · View at Scopus
- D. L. Bienvenue, D. M. Gilner, R. S. Davis, B. Bennett, and R. C. Holz, “Substrate specificity, metal binding properties, and spectroscopic characterization of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae,” Biochemistry, vol. 42, no. 36, pp. 10756–10763, 2003. View at Publisher · View at Google Scholar · View at Scopus
- K. S. Makarova and N. V. Grishin, “The Zn-peptidase superfamily: functional convergence after evolutionary divergence,” Journal of Molecular Biology, vol. 292, no. 1, pp. 11–17, 1999. View at Publisher · View at Google Scholar · View at Scopus
- J. Badger, J. M. Sauder, J. M. Adams et al., “Structural analysis of a set of proteins resulting from a bacterial genomics project,” Proteins, vol. 60, no. 4, pp. 787–796, 2005. View at Publisher · View at Google Scholar · View at Scopus
- B. P. Nocek, D. M. Gillner, Y. Fan, R. C. Holz, and A. Joachimiak, “Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase,” Journal of Molecular Biology, vol. 397, no. 3, pp. 617–626, 2010. View at Publisher · View at Google Scholar · View at Scopus
- V. M. Krishnamurthy, G. K. Kaufman, A. R. Urbach et al., “Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding,” Chemical Reviews, vol. 108, no. 3, pp. 946–1051, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. A. Marks and R. Breslow, “Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug,” Nature Biotechnology, vol. 25, no. 1, pp. 84–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Cushman and M. A. Ondetti, “Design of angiotensin converting enzyme inhibitors,” Nature Medicine, vol. 5, no. 10, pp. 1110–1112, 1999. View at Publisher · View at Google Scholar · View at Scopus
- D. H. Broder and C. G. Miller, “DapE can function as an aspartyl peptidase in the presence of Mn2+,” Journal of Bacteriology, vol. 185, no. 16, pp. 4748–4754, 2003. View at Publisher · View at Google Scholar · View at Scopus
- H. J. Vogel and D. M. Bonner, “Acetylornithinase of Escherichia coli: partial purification and some properties,” The Journal of Biological Chemistry, vol. 218, no. 1, pp. 97–106, 1956. View at Google Scholar · View at Scopus
- C. Gilvarg, “N-Succinyl-L-diaminopimelic acid,” The Journal of Biological Chemistry, vol. 234, pp. 2955–2959, 1959. View at Google Scholar · View at Scopus