DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes

<table>The changes in the absorbance of fixed amount of each metal complex in the interaction with varying amount of CT-DNA at 300 K and 310 K. The linear plot of the reciprocal of <svg height="11.4625" id="M60" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 23.475 11.4625" width="23.475" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.4)"><path d="M600 0h-557v24l268 633l28 8l261 -641v-24zM497 50l-194 489l-196 -489h390z" id="x394"></path></g><g transform="matrix(.017,-0,0,-.017,10.959,11.4)"><path d="M716 28l-8 -28h-254l8 28q55 5 66 17.5t5 47.5l-30 145h-232l-74 -138q-21 -43 -11 -54.5t72 -17.5l-6 -28h-235l8 28q53 7 73.5 21t53.5 70l319 540l33 8q6 -43 33 -176l80 -381q10 -49 26.5 -63t72.5 -19zM495 281l-49 264h-2l-149 -264h200z" id="x1D434"></path></g>
</svg> versus the reciprocal of [DNA] for [Pt(bpy)(Oct-dtc)]NO<sub>3</sub> and the inset for [Pd(bpy)(Oct-dtc)]NO<sub>3</sub>.</table>

Bioinorganic Chemistry and Applications

fig5

Figure 5

Figure 5: DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes 