DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes

Table 1

Thermodynamic parameters of CT-DNA denaturation by palladium(II) and platinum(II) complexes.

Compound	Temperature (𝐾)	^am (kJ/mol) (mmol/L)^−1	^bΔ𝐺^∘(H2O) (kJ/molK)	^cΔ𝐻^∘(H2O) (kJ/mol)	^dΔ𝑆^∘(H2O) (kJ/mol)
[Pt(bpy)(Oct-dtc)]NO3	300	123	8.30	34.5	0.08
	310	133	7.40
[Pd(bpy)(Oct-dtc)]NO3	300	195	13.44	28.09	0.05
	310	218	12.93

^aMeasure of the metal complex ability to denature CT-DNA.
^bConformational stability of CT-DNA in the absence of metal complex.
^cThe heat needed for CT-DNA denaturation in the absence of metal complex.
^dThe entropy of CT-DNA denaturation by metal complex.