DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes

Table 3

Binding parameters for the effect of platinum and palladium complexes on the fluorescence of EBr in the presence of CT-DNA.

Compound	^a𝑟f	^b𝐾 × 10^5 (M)^−1	^c𝑛
[Pt/Pd(bpy)(Oct-dtc)]NO3	0.00	1.68	0.0078
[Pt(bpy)(Oct-dtc)]NO3	0.55	1.04
	1.185	0.72
	1.85	0.55
[Pd(bpy)(Oct-dtc)]NO3	0.2	1.08	0.0078
	0.58	0.78
	0.92	0.56

^aFormal ratio of metal complex to nucleotide concentration.
^bAssociation constant.
^cNumber of binding sites (𝑛) per nucleotide.