Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV): Novel Metal-Based Complex with Promising Antitumor Potential

Figure 3

Chromatograms of DPDFT in plasma sample. Separation was performed using Waters 2695 HPLC system. The mobile phase consisted of phosphoric acid in water (solvent A)/methanol (solvent B) (30 : 70, V/V, pH 3.0) using Diamonsil C₁₈ column at 25°C with a flow rate of 0.8 mL·min⁻¹. (a) Blank plasma; (b) blank plasma spiked with DPDFT (3 μg·mL⁻¹) and the I.S. (8 μg·mL⁻¹); (c) blood sample containing DPDFT (2.4 μg·mL⁻¹) collected at 3 min after administration of DPDFT (15 mg·kg⁻¹, i.v.).

(a)

(b)

(c)