Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV): Novel Metal-Based Complex with Promising Antitumor Potential

Table 4

Mean pharmacokinetic parameters in rats after intravenous administration of 7.5, 15, and 30 mg·kg⁻¹ of DPDFT (mean ± SD, 𝑛=6).

Parameter (unit)	Dosage/mg kg^−1
	7.5 (low)	15 (middle)	30 (high)
A/min^−1	2.21±0.03	7.94±3.12	22.36±8.12
B/mg·kg^−1	0.15±0.04	0.92±0.04	1.85±0.44
β/min^−1	0.04±0.003	0.04±0.003	0.04±0.003
𝑉𝑑/L·kg^−1	2.13±0.07	1.13±0.08	0.62±0.08
𝑡1/2𝑎/min	1.04±0.01	1.01±0.01	1.12±0.1
𝑡1/2𝛽/min	17.68±2.6	19.38±3.6	16.81±3.6
𝐾21/min^−1	0.08±0.004	0.11±0.01	0.09±0.01
𝐾10/min^−1	0.32±0.05	0.24±0.08	0.30±0.18
𝐾12/min^−1	0.26±0.04	0.38±0.01	0.28±0.11
AUC/mg·kg^−1min^−1	7.56±1.02	37.15±3.06	81.25±15.3
CL(s)/mg·mL^−1, mg kg^−1	0.66±0.05	0.27±0.02	0.018±0.02