Synthesis, Characterization and In Vitro Antibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone (H₂dampt)

Table 4

Antibacterial activity^a,b of the free ligand (1) and its organotin(IV) complexes 2–6 (inhibition zone in mm).

Bacterium	Clinical implication	Zone of Inhibition (mm)
		(1)	(2)	(3)	(4)	(5)	(6)	R
Escherichia coli	Infection of wounds, urinary tract, and dysentery	24	12	20	21	28	29	34
Staphylococcus aureus	Food poisoning, scaled skin syndrome, endocarditis	14	22	24	—	29	30	36
Enterobacter aerogenes	Lower respiratory tract infections, skin and soft-tissue infections	—	—	20	22	20	22	26
Salmonella typhi	Typhoid fever, localized infection	21	—	14	23	23	27	31

^aIn vitro, agar-well diffusion method, conc. 200 mg/mL of DMSO. ^bReference drug (R), doxycycline, dash indicate inactivity.