Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands

Scheme 1

Synthesis route for the shikimic acid derivate ligands and Pt(II) complexes (𝑛=2, 3, 4, 5, 6): (i) CbzCl, NaHCO₃, H₂O; (ii) MsCl/py/20°C, excess NH₂(CH₂)₂NH₂; (iii) (t-BuO)₂CO, CH₂Cl₂; (iv) HCO₂NH₄/Pd/C; (v) Shikimic acid, DCC, HOBt; (vi) conc. HCl/MeOH/CH₂Cl₂; (vii) Na₂CO₃, K₂PtCl₄.