Cytotoxicity and In Vitro Antileishmanial Activity of Antimony (V), Bismuth (V), and Tin (IV) Complexes of Lapachol

Table 2

Antileishmanial activity, cytotoxicity, and selective indexes of tested compounds for HepG2 cells and murine macrophages.

Compound	Formula	IC50^a	HepG2		Macrophages
			MLD^b50	SI^c	MLD^b50	SI^c
(𝟏)	(Lp)(Ph3Bi)O0.5	29.05±18.45	58.38±8.47	2.01	32.4±8.20	1.11
(𝟐)	(Lp)(Ph3Sb)OH	18.27±5.58	325.22±89.40	17.81	130.65±40.52	7.15
(𝟑)	(Lp)(Ph3Sn)	0.17±0.03	12.01±0.17	70.65	1.6±0.57	9.41
(𝟒)	Ph3BiCl2	5.40±0.16	183.75±4.77	34.03	25.15±0.49	4.67
(𝟓)	Ph3SbCl2	11.61±7.85	157.46±37.13	13.56	30.75±6.01	2.65
(𝟔)	Ph3SnCl2	0.10±0.11	12.04±8.42	120.35	0.73±0.13	7.30
(𝟕)	Lp^d	15.48±5.23	201.77±5.32	13.03	184.65±6.58	11.92
Amphotericin B		0.73±0.60	644.59±126.57	883.00	179.95±8.84	246.51

aIC₅₀: the inhibitory concentration that killed 50% of the L. amazonensis in μg/mL.
^bMLD₅₀: the minimum lethal dose that killed 50% of the cells in μg/mL.
^cSI: selective index, calculated based on the MLD₅₀/IC₅₀ ratios.
^dLp: Lapachol.