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Bioinorganic Chemistry and Applications
Volume 2014 (2014), Article ID 325873, 8 pages
http://dx.doi.org/10.1155/2014/325873
Research Article

Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India

Received 15 May 2014; Revised 8 July 2014; Accepted 9 July 2014; Published 23 July 2014

Academic Editor: Igor O. Fritsky

Copyright © 2014 Rona Banerjee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mononuclear complexes of Curcumin with Cu(II) and Zn(II) have been synthesized and, characterized and their effects on the fibrillization and aggregation of amyloid-beta (Aβ) peptide have been studied. FTIR spectroscopy and atomic force microscopy (AFM) observations demonstrate that the complexes can inhibit the transition from less structured oligomers to β-sheet rich protofibrils which act as seeding factors for further fibrillization. The metal complexes also impart more improved inhibitory effects than Curcumin on peptide fibrillization.