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Bioinorganic Chemistry and Applications
Volume 2014 (2014), Article ID 382646, 8 pages
Research Article

Palladium(II) Complexes Containing Mixed Nitrogen-Sulphur Donor Ligands: Interaction of [Pd(Methionine Methyl Ester)(H2O)2]2+ with Biorelevant Ligands

1Department of Chemistry, Faculty of Science, Islamic University, Madinah, Saudi Arabia
2Department of Chemistry, Faculty of Science, Cairo University, P.O. Box 12613, Giza, Egypt

Received 30 May 2014; Accepted 21 July 2014; Published 24 August 2014

Academic Editor: Alberto Pettignano

Copyright © 2014 Mohamed M. Shoukry and Sameya M. T. Ezzat. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pd(MME)Cl2 complex (MME = methionine methyl ester) was synthesised and characterized by physicochemical measurements. The reaction of [Pd(MME)(H2O)2]2+ with amino acids, peptides, or dicarboxylic acids was investigated at 25°C and 0.1 M ionic strength. Amino acids and dicarboxylic acids form 1 : 1 complexes. Peptides form both 1 : 1 complexes and the corresponding deprotonated amide species. The stability of the complexes formed was determined and the binding centres of the ligands were assigned. Effect of solvent on the stability constant of Pd(MME)-CBDCA complex, taken as a representative example, shows that the complex is more favoured in a medium of low dielectric constant. The concentration distribution diagrams of the complexes were evaluated.