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Bioinorganic Chemistry and Applications
Volume 2014 (2014), Article ID 926287, 17 pages
Research Article

Transition Metal(II) Complexes with Cefotaxime-Derived Schiff Base: Synthesis, Characterization, and Antimicrobial Studies

1Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Craiova, 107I Calea Bucureşti, 200478 Craiova, Romania
2Department of Microbiology, Faculty of Biology, University of Bucharest, 1-4 Aleea Portocalelor, 60101 Bucharest, Romania
3Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 66, 1 May Street, 200638 Craiova, Romania

Received 7 October 2013; Revised 23 December 2013; Accepted 27 December 2013; Published 12 February 2014

Academic Editor: Claudio Pettinari

Copyright © 2014 Aurora Reiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New [ML2(H2O)2] complexes, where M = Co(II), Ni(II), Cu(II), and Zn(II) while L corresponds to the Schiff base ligand, were synthesized by condensation of cefotaxime with salicylaldehyde in situ in the presence of divalent metal salts in ethanolic medium. The complexes were characterized by elemental analyses, conductance, and magnetic measurements, as well as by IR and UV-Vis spectroscopy. The low values of the molar conductance indicate nonelectrolyte type of complexes. Based on spectral data and magnetic moments, an octahedral geometry may be proposed for Co(II), Ni(II), and Zn(II) complexes while a tetragonal geometry for Cu(II) complex. Molecular structure of the Schiff base ligand and its complexes were studied using programs dedicated to chemical modeling and quantomolecular calculation of chemical properties. All the synthesized complexes were tested for in vitro antibacterial activity against some pathogenic bacterial strains, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus. The MIC values shown by the complexes against these bacterial strains revealed that the metal complexes possess superior antibacterial activity than the Schiff base.