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Bioinorganic Chemistry and Applications
Volume 2015 (2015), Article ID 428121, 12 pages
Research Article

Novel Synthesis Method of Micronized Ti-Zeolite Na-A and Cytotoxic Activity of Its Silver Exchanged Form

1Refractories, Ceramics and Building Materials Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt
2Department of Chemistry, Faculty of Science, Suez University, Suez 43533, Egypt
3Biomaterials Department, National Research Centre (NRC), Dokki, Cairo 12622, Egypt

Received 26 November 2014; Revised 27 December 2014; Accepted 30 December 2014

Academic Editor: Francesco P. Fanizzi

Copyright © 2015 H. F. Youssef et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The core-shell method is used as a novel synthetic process of micronized Ti-Zeolite Na-A which involves calcination at 700°C of coated Egyptian Kaolin with titanium tetrachloride in acidic medium as the first step. The produced Ti-coated metakaolinite is subjected to microwave irradiation at low temperature of 80°C for 2 h. The prepared micronized Ti-containing Zeolites-A (Ti-Z-A) is characterized by FTIR, XRF, XRD, SEM, and EDS elemental analysis. Ag-exchanged form of Ti-Z-Ag is also prepared and characterized. The Wt% of silver exchanged onto the Ti-Zeolite structure was determined by atomic absorption spectra. The in vitro cytotoxic activity of Ti-Z-Ag against human hepatocellular carcinoma cell line (HePG2), colon cell line carcinoma (HCT116), lung carcinoma cell line (A549), and human Caucasian breast adenocarcinoma (MCF7) is reported. The results were promising and revealed that the exchanged Ag form of micronized Ti-Zeolite-A can be used as novel antitumor drug.