Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td align="left">Compounds</td><td align="center"><b>3</b></td><td align="center"><b>6</b></td><td align="center"><b>9</b></td><td align="center"><b>11</b></td><td align="center"><b>14</b></td><td align="center">Cisplatin</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td align="left">SI<svg height="6.67159pt" id="M99" style="vertical-align:-3.27284pt" version="1.1" viewbox="-0.0498162 -3.39875 31.3769 6.67159" width="31.3769pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,3.132)"><path d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 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horiz-adv-x="493" vert-adv-y="493"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,26.147,3.132)"><path d="M465 179V225H369V632H330C227 497 124 346 29 205V179H289V107C289 37 284 33 198 26V0H454V26C374 33 369 37 369 107V179H465ZM289 225H92C156 335 222 430 287 520H289V225Z" id="g190-166"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="497" vert-adv-y="497"></glyph.data></g></svg></td><td align="center">5.1</td><td align="center">2.3</td><td align="center">—</td><td align="center">—</td><td align="center">1.9</td><td align="center">—</td></tr><tr><td align="left">SI<svg height="6.12355pt" id="M100" style="vertical-align:-3.27284pt" version="1.1" viewbox="-0.0498162 -2.85071 20.3091 6.12355" width="20.3091pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,3.132)"><path d="M729 650H468V622C546 615 554 610 554 527V365H213V527C213 610 221 616 297 622V650H38V622C120 616 128 611 128 527V123C128 39 120 34 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31 519 126 525 157L495 163Z" id="g190-77"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="538" vert-adv-y="538"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,15.642,3.132)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 -12 237 25 277 52C282 35 288 21 301 8C312 -3 333 -12 348 -12L433 39ZM275 84C256 65 221 48 195 48C164 48 124 73 124 124C124 161 146 180 185 198C206 208 254 229 275 240V84Z" id="g190-98"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="439" vert-adv-y="439"></glyph.data></g></svg></td><td align="center">8.7</td><td align="center">21.7</td><td align="center">1.3</td><td align="center">—</td><td align="center">2.0</td><td align="center">1.0</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

SI values of steroidal thiosemicarbazone Pt-complexes.

Bioinorganic Chemistry and Applications

tab2

Table 2

Table 2: Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes 