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Bioinorganic Chemistry and Applications
Volume 2015, Article ID 890734, 9 pages
Research Article

Synthesis, Characterization, Antioxidant, and Antibacterial Studies of Some Metal(II) Complexes of Tetradentate Schiff Base Ligand: (4E)-4-[(2-(E)-[1-(2,4-Dihydroxyphenyl)ethylidene]aminoethyl)imino]pentan-2-one

Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa

Received 28 February 2015; Accepted 8 April 2015

Academic Editor: Claudio Pettinari

Copyright © 2015 Ikechukwu P. Ejidike and Peter A. Ajibade. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Co(II), Ni(II), Cu(II), and Zn(II) complexes of (4E)-4-[(2-(E)-[1-(2,4-dihydroxyphenyl)ethylidene]aminoethyl)imino]pentan-2-one have been synthesized and characterized by elemental analyses, molar conductance, electronic and IR spectral studies, and XRD. FTIR confirmed the ligand coordinates the metal ion to form mononuclear complex via the oxygen and nitrogen atoms of the phenolic group and azomethine group, respectively. Tetrahedral geometry is proposed for Co(II) complex and square-planar geometry for Ni(II) and Cu(II) complexes. The antibacterial studies of the compounds were determined and they show that the metal complexes are more active than the free ligands. The antioxidant activity by DPPH and ABTS method was examined and it shows Cu(II); IC50 = 2.31 ± 1.54 µM for DPPH and Co(II); IC50 = 1.83 ± 1.08 µM for ABTS were the most active.