Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity

<div>General synthetic procedure for compounds L5, L6, 1 and 2. a: NBS (1.1 equiv), CF3COOH, room temperature, 2 h; b: NaOH, H2O, CH3OCH2Cl, anhydrous acetone, anhydrous pyridine, room temperature, 2 h; c: n-BuLi 1.6 M, anhydrous THF, −78°C → room temperature, CO2 (10 min.); d: HCl 2M, i-PrOH, THF, room temperature, 16 h; e: [Pt(dach)(OH2)2](NO3)2 or [Pt(dach)(OH2)(OSO3)], H2O, room temperature, 16 h.</div>

Bioinorganic Chemistry and Applications

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Scheme 1

Scheme 1: Oxaliplatin Analogues with Carboxy Derivatives of Boldine with Enhanced Antioxidant Activity 