Table of Contents Author Guidelines Submit a Manuscript
Bioinorganic Chemistry and Applications
Volume 2016, Article ID 2380540, 7 pages
http://dx.doi.org/10.1155/2016/2380540
Research Article

Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes

Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy

Received 25 July 2016; Accepted 8 September 2016

Academic Editor: Viktor Brabec

Copyright © 2016 Mauro Ravera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Bertrand, J. Wu, X. Xu, N. Kamaly, and O. C. Farokhzad, “Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology,” Advanced Drug Delivery Reviews, vol. 66, pp. 2–25, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. J. M. Rademaker-Lakhai, C. Terret, S. B. Howell et al., “A phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors,” Clinical Cancer Research, vol. 10, no. 10, pp. 3386–3395, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Liu, C. He, A. Z. Wang, and W. Lin, “Application of liposomal technologies for delivery of platinum analogs in oncology,” International Journal of Nanomedicine, vol. 8, pp. 3309–3319, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Gabano, M. Ravera, and D. Osella, “The drug targeting and delivery approach applied to Pt-antitumour complexes. A coordination point of view,” Current Medicinal Chemistry, vol. 16, no. 34, pp. 4544–4580, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. L. M. Kaminskas, V. M. McLeod, C. J. H. Porter, and B. J. Boyd, “Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation,” Molecular Pharmaceutics, vol. 9, no. 3, pp. 355–373, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. Q.-H. Zhao and L.-Y. Qiu, “An overview of the pharmacokinetics of polymer-based nanoassemblies and nanoparticles,” Current Drug Metabolism, vol. 14, no. 8, pp. 832–839, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. Z. Xu, M. Guo, H. Yan, and K. Liu, “Enhanced loading of doxorubicin into polymeric micelles by a combination of ionic bonding and hydrophobic effect, and the pH-sensitive and ligand-mediated delivery of loaded drug,” Reactive & Functional Polymers, vol. 73, no. 3, pp. 564–572, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. J. Cleare and J. D. Hoeschele, “Anti-tumour platinum compounds. relationship between structure and activity,” Platinum Metals Review, vol. 17, no. 1, pp. 2–13, 1973. View at Google Scholar · View at Scopus
  9. M. J. Cleare and J. D. Hoeschele, “Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes,” Bioinorganic Chemistry, vol. 2, no. 3, pp. 187–210, 1973. View at Publisher · View at Google Scholar · View at Scopus
  10. M. J. Cleare, “Transition metal complexes in cancer chemotherapy,” Coordination Chemistry Reviews, vol. 12, no. 4, pp. 349–405, 1974. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Monti, M. B. Gariboldi, R. Ravizza et al., “Poly(methylmetacrylate) (PMMA) core–shell nanospheres act as efficient pharmacophores for the antiproliferative [PtCl3(NH3)] complex by forming ionic couples,” Inorganica Chimica Acta, vol. 362, no. 11, pp. 4099–4109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Gál, J. Híveš, M. Laus et al., “Electrostatic interaction of negatively charged core-shell nanoparticles with antitumoral cationic platinum-based complexes,” European Journal of Inorganic Chemistry, vol. 2011, no. 22, pp. 3289–3294, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Y. Park, J. J. Wilson, Y. Song, and S. J. Lippard, “Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 30, pp. 11987–11992, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. M. W. Kellinger, G. Y. Park, J. Chong, S. J. Lippard, and D. Wang, “Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis,” Journal of the American Chemical Society, vol. 135, no. 35, pp. 13054–13061, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. T. Gregory, G. Y. Park, T. C. Johnstone, Y.-S. Lee, W. Yang, and S. J. Lippard, “Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 25, pp. 9133–9138, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. T. C. Johnstone, S. M. Alexander, W. Lin, and S. J. Lippard, “Effects of monofunctional platinum agents on bacterial growth: a retrospective study,” Journal of the American Chemical Society, vol. 136, no. 1, pp. 116–118, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. T. C. Johnstone and S. J. Lippard, “The chiral potential of phenanthriplatin and its influence on guanine binding,” Journal of the American Chemical Society, vol. 136, no. 5, pp. 2126–2134, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. T. C. Johnstone, G. Y. Park, and S. J. Lippard, “Understanding and improving platinum anticancer drugs—phenanthriplatin,” Anticancer Research, vol. 34, no. 1, pp. 471–476, 2014. View at Google Scholar · View at Scopus
  19. R. Mehvar, “Dextrans for targeted and sustained delivery of therapeutic and imaging agents,” Journal of Controlled Release, vol. 69, no. 1, pp. 1–25, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Varshosaz, “Dextran conjugates in drug delivery,” Expert Opinion on Drug Delivery, vol. 9, no. 5, pp. 509–523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Heinze, T. Liebert, B. Heublein, and S. Hornig, “Functional polymers based on dextran,” in Polysaccharides II, D. Klemm, Ed., pp. 199–291, Springer, Berlin, Germany, 2006. View at Google Scholar
  22. D.-W. Shen, L. M. Pouliot, M. D. Hall, and M. M. Gottesman, “Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes,” Pharmacological Reviews, vol. 64, no. 3, pp. 706–721, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Aldieri, C. Riganti, F. Silvagno et al., “Antioxidants prevent the RhoA inhibition evoked by crocidolite asbestos in human mesothelial and mesothelioma cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 45, no. 3, pp. 625–631, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Orecchia, F. Schillaci, M. Salvio, R. Libener, and P.-G. Betta, “Aberrant E-cadherin and γ-catenin expression in malignant mesothelioma and its diagnostic and biological relevance,” Lung Cancer, vol. 45, pp. S37–S43, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Zanellato, C. D. Boidi, G. Lingua et al., “In vitro anti-mesothelioma activity of cisplatin-gemcitabine combinations: evidence for sequence-dependent effects,” Cancer Chemotherapy and Pharmacology, vol. 67, no. 2, pp. 265–273, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Magnani and E. Bettini, “Resazurin detection of energy metabolism changes in serum-starved PC12 cells and of neuroprotective agent effect,” Brain Research Protocols, vol. 5, no. 3, pp. 266–272, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Zanellato, I. Bonarrigo, D. Colangelo et al., “Biological activity of a series of cisplatin-based aliphatic bis(carboxylato) Pt(IV) prodrugs: how long the organic chain should be?” Journal of Inorganic Biochemistry, vol. 140, pp. 219–227, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Ravera, E. Gabano, I. Zanellato et al., “Cellular trafficking, accumulation and DNA platination of a series of cisplatin-based dicarboxylato Pt(IV) prodrugs,” Journal of Inorganic Biochemistry, vol. 150, pp. 1–8, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Ghezzi, M. Aceto, C. Cassino, E. Gabano, and D. Osella, “Uptake of antitumor platinum(II)-complexes by cancer cells, assayed by inductively coupled plasma mass spectrometry (ICP-MS),” Journal of Inorganic Biochemistry, vol. 98, no. 1, pp. 73–78, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. P. Yousefpour, F. Atyabi, E. V. Farahani, R. Sakhtianchi, and R. Dinarvand, “Polyanionic carbohydrate doxorubicin-dextran nanocomplex as a delivery system for anticancer drugs: in vitro analysis and evaluations,” International Journal of Nanomedicine, vol. 6, pp. 1487–1496, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Rejman, V. Oberle, I. S. Zuhorn, and D. Hoekstra, “Size-dependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis,” Biochemical Journal, vol. 377, no. 1, pp. 159–169, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Natile and F. Cannito, “Platinum drugs, nucleotides and DNA: the role of interligand interactions,” in Metal Complex-DNA Interactions, N. Hadjiliadis and E. Sletten, Eds., pp. 133–173, John Wiley & Sons, New York, NY, USA, 2009. View at Google Scholar
  33. N. J. Vogelzang, J. J. Rusthoven, J. Symanowski et al., “Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma,” Journal of Clinical Oncology, vol. 21, no. 14, pp. 2636–2644, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. E. Lindauer and E. Holler, “Cellular distribution and cellular reactivity of platinum(II) complexes,” Biochemical Pharmacology, vol. 52, no. 1, pp. 7–14, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Alessio, I. Zanellato, I. Bonarrigo, E. Gabano, M. Ravera, and D. Osella, “Antiproliferative activity of Pt(IV)-bis(carboxylato) conjugates on malignant pleural mesothelioma cells,” Journal of Inorganic Biochemistry, vol. 129, pp. 52–57, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. C.-B. He, Y.-P. Hu, L.-C. Yin, C. Tang, and C.-H. Yin, “Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles,” Biomaterials, vol. 31, no. 13, pp. 3657–3666, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Salatin, S. M. Dizaj, and A. Y. Khosroushahi, “Effect of the surface modification, size, and shape on cellular uptake of nanoparticles,” Cell Biology International, vol. 39, no. 8, pp. 881–890, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. V. Forest, M. Cottier, and J. Pourchez, “Electrostatic interactions favor the binding of positive nanoparticles on cells: A Reductive Theory,” Nano Today, vol. 10, no. 6, pp. 677–680, 2015. View at Publisher · View at Google Scholar · View at Scopus