Polyanionic Biopolymers for the Delivery of Pt(II) Cationic Antiproliferative Complexes

Table 1

Antiproliferative activity (IC₅₀ values, μM) after 72 h continuous treatment and cellular accumulation (AR, 4 h, 10 μM) of cisplatin, complex 3, and its conjugate 3-DS.

Complex	IC50 (μM)						AR; (A2780)
	A2780	HCT 116	BR95	MG06	MM98	MM98R
Cisplatin	0.46 ± 0.11	2.32 ± 0.35	6.2 ± 0.9	4.1 ± 1.5	3.2 ± 1	19.4 ± 2.8 (6.1)	0.62 ± 0.12
3	0.12 ± 0.02	0.76 ± 0.09	1.32 ± 0.02	0.72 ± 0.14	0.86 ± 0.12	2.09 ± 0.06 (2.4)	4.81 ± 1.08
3-DS	0.20 ± 0.04	1.19 ± 0.02	2.13 ± 0.29	1.03 ± 0.09	1.83 ± 0.11	3.46 ± 0.36 (1.9)	3.03 ± 0.57

Data are means ± SD of at least three independent experiments performed in triplicate. Data in brackets are the resistance factor RF = IC₅₀ (MM98R)/IC₅₀ (MM98). The AR value of 3-DS was compared to that of free 3 by means of the two-sample -test ( < 0.5).