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Bioinorganic Chemistry and Applications
Volume 2017, Article ID 4736321, 6 pages
https://doi.org/10.1155/2017/4736321
Research Article

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

1Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia
2Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia
3Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, Moscow 119334, Russia
4I.M. Sechenov First Moscow State Medical University, Moscow, Russia
5Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1019 Vienna, Austria

Correspondence should be addressed to Alexey A. Nazarov; moc.em@vorazan.yexela

Received 5 April 2017; Revised 4 June 2017; Accepted 8 June 2017; Published 19 July 2017

Academic Editor: Giovanni Natile

Copyright © 2017 Yulia N. Nosova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.