Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

Table 1

Cytotoxicity of new complexes, bexarotene, cisplatin, and oxaliplatin.

Compounds	IC50 (µM)
	SW480	A549	MCF7	MCF7D	HaCat
3	>100	83 ± 16	>100	>100	>100
4	11 ± 1.6	10 ± 1	0.47 ± 0.07	4.8 ± 0.5	8 ± 1.3
Bexarotene	80 ± 10	85 ± 9	67 ± 13	71 ± 21	>90
Cisplatin	14 ± 4.4	29.0 ± 10	14 ± 7	75 ± 5.8	30 ± 10
Oxaliplatin	0.9 ± 0.3; [34]	11.5 ± 3.9; [34]	43.8; [35]	—	—

Data are mean standard deviation from 3 independent experiments; each drug concentration was tested in triplicate. —: no data.