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Bioinorganic Chemistry and Applications
Volume 2018, Article ID 1439810, 12 pages
Research Article

Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts

Department of Chemistry, Trakya University, 22030 Edirne, Turkey

Correspondence should be addressed to Gühergül Uluçam; rt.ude.aykart@lugrelug

Received 11 February 2018; Revised 11 April 2018; Accepted 17 April 2018; Published 22 May 2018

Academic Editor: Rais A. Khan

Copyright © 2018 Gühergül Uluçam and Murat Turkyilmaz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. The in vitro biological activities of the salts on the selected bacteria and cancer cell lines were determined by using the broth dilution method according to Clinical and Laboratory Standards Institute guidelines. The 1,3-bis(2-hydroxyethyl) imidazolidinium bromide and 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide showed efficiency on Bacillus cereus ATCC 11778. The 3-bis(2-carboxyethyl)-4-methyl-1-H-imidazol-3-ium bromide was effective on HeLa while a similar effect was observed on Hep G2 with 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide.