Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts

Table 7

Half inhibition concentrations of the molecules on the selected bacteria and cancer cell lines.

	Antibacterial activity IC50 (µM)			Cytotoxic activity IC50 (µM)
	Escherichia coli O157:H7	Candida albicans	Bacillus cereus	HeLa	Hep G2	MEF
LA	32	30	17	316	100	—
LB	39	156	29	141	182	—
LC	—	—	—	81	150	—
LD	—	—	—	167	57	—
Antibiotic	10	30	56	—	—	—

L_A, 1,3-bis(2-hydroxyethyl) imidazolidinium bromide; L_B, 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide; L_C, 1,3-bis(2-carboxyethyl)-4-methyl-1H-imidazol-3-ium bromide; L_D 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide; IC₅₀, half inhibitory concentrations; HeLa, human cervical cancer cell line; Hep G2, human liver cancer cell line; MEF, healthy mouse embryonic fibroblast cell line.