Synthesis, Characterization, and Biological Evaluation of Unimetallic and Heterobimetallic Complexes of Bivalent Copper

Table 3

Hepatoprotective activity of heterobimetallic complexes of Cu(II).

Group of animals	Time in weeks				F value	C.D at 5%
	I	II	III	IV
Total bilirubin
Control	0.85 ± 0.10	0.86 ± 0.79	0.73 ± 0.06	0.86 ± 0.69	2.74	0.018
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	1.32 ± 0.75	1.48 ± 0.38	1.56 ± 0.45	1.61 ± 0.18	15.1	0.071
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	1.46 ± 0.50	1.52 ± 0.08	1.75 ± 0.10	1.80 ± 0.08	46.8	0.084
CCl4	1.80 ± 0.05	2.30 ± 0.60	2.75 ± 0.15	3.70 ± 0.41	55.2	0.315
Total protein
Control	7.24 ± 0.23	6.87 ± 0.22	6.90 ± 0.25	7.08 ± 0.10	0.451	0.442
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	6.67 ± 0.25	6.44 ± 0.20	6.40 ± 0.30	6.30 ± 0.24	3.10	0.348
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	6.50 ± 0.16	6.39 ± 0.27	6.36 ± 0.25	6.15 ± 0.22	4.69	0.342
CCl4	5.98 ± 0.24	5.20 ± 0.17	4.82 ± 0.29	4.19 ± 0.17	39.6	0.350
Albumin
Control	4.68 ± 0.25	4.50 ± 0.20	4.50 ± 0.20	4.78 ± 0.30	0.45	0.376
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	4.23 ± 0.37	3.97 ± 0.17	3.75 ± 0.25	3.55 ± 0.20	4.49	0.366
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	3.72 ± 0.24	3.62 ± 0.40	3.60 ± 0.25	3.42 ± 0.17	1.61	0.416
CCl4	3.50 ± 0.20	2.50 ± 0.25	1.97 ± 0.40	1.35 ± 0.12	414.9	0.405
Globulin
Control	2.40 ± 0.81	2.35 ± 0.10	2.34 ± 0.73	2.30 ± 0.17	0.18	0.207
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	2.53 ± 0.14	2.53 ± 0.24	2.67 ± 0.19	2.57 ± 0.14	1.44	0.150
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	2.67 ± 0.19	2.73 ± 0.18	2.74 ± 0.31	2.79 ± 0.12	1.23	0.295
CCl4	2.58 ± 0.10	2.62 ± 0.10	2.80 ± 0.16	2.80 ± 0.15	5.80	0.183
Aspartate aminotransaminase
Control	0.45 ± 0.10	7.50 ± 0.24	7.78 ± 0.50	9.20 ± 0.20	12.9	0.598
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	11.55 ± 0.40	14.25 ± 0.35	13.90 ± 0.55	15.10 ± 0.35	56.10	0.580
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	13.0 ± 0.40	14.15 ± 0.24	14.32 ± 0.25	16.40 ± 0.65	52.61	0.602
CCl4	16.80 ± 0.40	22.20 ± 0.80	25.76 ± 0.70	32.20 ± 1.0	245.7	1.160
Alanine aminotransaminase
Control	9.65 ± 0.65	9.85 ± 0.51	8.65 ± 0.20	8.40 ± 0.65	7.90	6.729
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	14.32 ± 0.27	14.82 ± 0.63	14.82 ± 0.79	15.93 ± 0.45	8.95	0.896
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	12.73 ± 0.62	13.24 ± 0.66	14.04 ± 0.52	14.42 ± 0.27	5.18	0.990
CCl4	16.10 ± 0.30	20.90 ± 0.24	26.00 ± 0.43	33.40 ± 1.5	265.0	1.376
Alkaline phosphatase
Control	9.67 ± 0.50	9.85 ± 0.50	8.65 ± 0.20	8.45 ± 0.64	7.75	0.728
[Cu(C6H5N2F)2Sn2(Ph)4Cl2]	12.85 ± 0.50	14.83 ± 0.52	14.06 ± 0.52	14.48 ± 0.30	5.18	0.985
[Cu(C6H5N2F)2Sn2(CH3)4Cl2]	13.40 ± 0.60	14.77 ± 0.43	14.87 ± 0.43	15.61 ± 0.42	8.95	0.886
CCl4	16.10 ± 0.34	20.24 ± 0.24	25.00 ± 0.44	33.60 ± 1.46	263.5	1.278