Research Article
Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations
Table 4
Cytotoxic activity of tested complexes against human cancer cell lines.
| Cell type | IC50 (µg/ml) | HL1 | Ag(I)-HL1 | HL2 | Ag(I)-HL2 | HL3 | Ag(I)-HL3 | HL4 | Ag(I)-HL4 | Doxorubicin |
| MCF-7 | 60.4 | 60.8 | 57.7 | 78.8 | 14.5 | 12.81 | 1.976 | 16.66 | 0.168 | HepG2 | 71.3 | 62.32 | 63.52 | 88.5 | 17.8 | 11.88 | 15.86 | 12.52 | 0.777 | HCT116 | 36.5 | 26.8.5 | 52.6 | 45.8 | 20.4 | 12.8 | 14.8 | 8.42 | 0.9255 |
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