Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes

Table 2

Comparison of the catalytic activities between 1a and [{Pt(en)(H₂O)}₂(-pz)]⁴⁺ [35] and 3a and [{Pt(en)(H₂O)}₂(-pydz)]⁴⁺ [44] complexes in the hydrolysis of Ac–L–Met–Gly dipeptide.

Platinum(II) complex	Hydrolyzed Met-Gly amide bond (%)
	2 h	12 h	24 h
[{Pt(en)(H2O)}2(-qx)]^4+ (1a)	35	52	60
[{Pt(en)(H2O)}2(-pz)]^4+	60	85	88
[{Pt(en)(H2O)}2(-phtz)]^4+(3a)	8	28	41
[{Pt(en)(H2O)}2(-pydz)]^4+	12	36	54