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Bioinorganic Chemistry and Applications
Volume 2018, Article ID 7563820, 7 pages
https://doi.org/10.1155/2018/7563820
Research Article

Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes

1Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
2Department of Zoology and Environmental Science, University of Colombo, Colombo, Sri Lanka

Correspondence should be addressed to Theshini Perera; kl.ca.pjs@ihseht

Received 18 August 2017; Revised 9 November 2017; Accepted 28 November 2017; Published 18 February 2018

Academic Editor: Francesco Paolo Fanizzi

Copyright © 2018 Nalin Abeydeera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Four Zn(II) complexes containing a pyridyl triazine core (L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl2]·5H2O·ZnCl2 (1), [Zn(L1)2Cl2]·4H2O·2CH3OH (2), [Zn(L2)Cl2]·3H2O·CH3OH (3), and [Zn(L2)2Cl2] (4). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and 1H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes 14 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes 14 with bovine serum albumin (BSA) resulted binding constants (Kb) of 3.09 × 104 M−1, 12.30 × 104 M−1, and 16.84 × 104 M−1 for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins.