Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death

Figure 5

Time course of frequency change (ΔF (Hz)) of IPHs-DR5 complexation. Conditions: temperature, 25°C; solvent, phosphate-buffered saline (PBS). An aliquot of solutions of TRAIL (red curve) (200 µg/mL), 5 (green curve), 6 (blue curve), 9 (orange curve), and 2c (black curve) ([Ir complex] = 10 mM solution in DMSO) was added to DR5 fixed on the sensor chip. Plain arrows indicate the time when solutions of these analytes were added to DR5.