Research Article
β-Carboline Silver Compound Binding Studies with Human Serum Albumin: A Comprehensive Multispectroscopic Analysis and Molecular Modeling Study
Table 4
Noncovalent interactions of compound 1 with the HSA binding site IIA.
| | Name | Distance (Å) | Category | Type |
| | ARG257: H11-Complex 1: O1′ | 2.81 | Hydrogen bond | Conventional | | HIS288: H1-compound 1: O3 | 1.68 | | Compound 1: O1′-GLU153: O1 | 3.24 | | Compound 1: Cl1-GLU153: O1 | 3.63 | Electrostatic | Attractive charge | | GLN196-compound 1 | 3.32 | Hydrophobic | π-Sigma | | HIS242-compound 1 | 4.78 | π-π Stacked | | HIS242-compound 1 | 3.92 | π-π Stacked | | Compound 1-LYS199 | 5.38 | π-Alkyl | | Compound 1-LYS199 | 4.19 | π-Alkyl | | Compound 1-LYS195 | 4.75 | π-Alkyl | | Compound 1-LYS199 | 5.03 | π-Alkyl | | Compound 1-CYS200 | 5.25 | π-Alkyl | | Compound 1-CYS245 | 4.23 | π-Alkyl | | Compound 1-CYS246 | 4.92 | π-Alkyl |
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