Antimicrobial Activity and DNA/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane/ethene as Bridging Ligands

Table 1

Antimicrobial activity of silver(I) complexes 1–3 and the respective bpa and bpe ligands (MIC, μg/mL) in comparison to their cytotoxic effect on the normal human fibroblast cell line MRC-5 (IC₅₀, μg/mL).

Test organism	Compound
	1	2	3	bpa	bpe
E. coli; NCTC 9001	12.5^a	12.5	12.5	>500	250
P. aeruginosa; PAO1	50	200	25	>500	500
L. monocytogenes; NCTC 11994	50	50	25	>500	100
S. aureus; ATCC 43300	50	200	100	>500	>500
E. faecalis; ATCC 29212	12.5	25	25	>500	>500
S. enteritidis; ATCC 13075	50	50	200	>500	>500
S. pullorum; ATCC 13036	25	12.5	250	>500	>500
C. albicans; ATCC 10231	6.25	6.25	25	125	200
C. parapsilosis; ATCC 22019	3.1	2.5	3.1	250	125
C. glabrata; ATCC 2001	6.25	12.5	25	>500	100
C. krusei; ATCC 6258	6.25	3.1	6.25	125	200
MRC-5 cells	40^b	30	40	300	220

^aResults are given as mean of three independent measurements with a standard error being between 1% and 3%. ^bCalculated IC₅₀ values correspond to the concentrations required to inhibit 50% of the cell growth.