Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells

Table 2

The nonlinear regression sigmoidal dose-response curve calculated the different IC₅₀ values of ZnO-NPs for the breast cancer cell lines (MCF7 and MDA-MB-231) and HFF.

		MCF7	MDA-MB-231	HFF
IC50	24 h	11.16 μg/mL	60.08 μg/mL	26.3 μg/mL
	48 h	7.736 μg/mL	53.28 μg/mL	24.76 μg/mL
	72 h	4.941 μg/mL	55.83 μg/mL	22.34 μg/mL
Log IC50	24 h	1.048 μg/mL	1.779 μg/mL	1.42 μg/mL
	48 h	0.8885 μg/mL	1.727 μg/mL	1.394 μg/mL
	72 h	0.6938 μg/mL	1.747 μg/mL	1.349 μg/mL

Abbreviations: MCF7: Michigan Cancer Foundation-7, HFF: human foreskin fibroblasts, IC₅₀: the half-maximal inhibitory concentration, and log: logarithm.