Research Article
Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro
Table 2
IC50 values (μM) of complexes 1, 2, and 3 against human cell lines.a
| | Complex | MCF-7 | SGC-7901 | Eca-109 | HepG2 | HSF |
| | Trp + sal + Ni + phen (1) | 75.75 ± 0.41 | 33.99 ± 2.50 | 23.95 ± 2.54 | >80.00 | 60.94 ± 1.76 | | Trp + o-van + Ni + phen (2) | 16.09 ± 1.32 | 15.69 ± 1.46 | 18.14 ± 2.39 | 47.29 ± 0.35 | 23.91 ± 0.74 | | Trp + naph + Ni + phen (3) | 23.74 ± 0.55 | 24.29 ± 0.95 | 21.89 ± 3.19 | 28.11 ± 1.34 | 32.54 ± 1.98 | | L1 | >80.00 | >80.00 | >80.00 | >80.00 | —— | | L2 | >80.00 | >80.00 | >80.00 | >80.00 | —— | | L3 | >80.00 | 42.70 ± 1.13 | 48.36 ± 4.99 | >80.00 | —— | | Ni (CH3COO)2 | >80.00 | 41.35 ± 0.87 | 43.51 ± 1.34 | >80.00 | —— | | Cisplatin | 12.34 ± 0.75 | 11.73 ± 1.45 | 11.87 ± 0.19 | 13.94 ± 0.58 | 17.13 ± 1.31 |
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aCell viability was determined by MTT assay after treatment for 48 h.
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