Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives

Table 8

Bactericidal activity screening test levels of the ligands and complexes (100 μg/mL)^a.

Compounds	Inhibition ratio (%) (Levels^c)
	E. coli^b	S. aureus^b	S. typhimurium^b	B. subtilis^b	Sh. flexneri^b	V. parahaemolyticus^b	P. aeruginosa^b
L1	84.9	81.5	77.2	73.9	96.3	74.8	97.1
	(++)	(++)	(++)	(++)	(+++)	(++)	(+++)
L2	101.7	55.4	77.0	99.1	98.7	14.3	79.2
	(+)	(−)	(+)	(+++)	(+++)	(−)	(+)
1	73.9	97.3	99.7	102.0	99.2	98.7	43.8
	(++)	(+++)	(+++)	(+++)	(+++)	(+++)	(−)
2	102.3	102.2	96.3	54.6	100.0	40.4	101.3
	(+++)	(+++)	(+++)	(+++)	(+++)	(−)	(+++)

^aBactericidal activity is revealed by the percentage of complexes against bacterial strain. ^bEscherichia coli (E. coli, ATCC 25922), Staphylococcus aureus (S. aureus, CMCC(B) 26003), Salmonella typhimurium (S. typhimurium, CMCC(B) 50071), Bacillus subtilis (B. subtilis, ATCC 6633), Shigella flexneri (Sh. flexneri, CMCC(B) 51572), Vibrio parahaemolyticus (V. parahaemolyticus, ATCC 17802), Pseudomonas aeruginosa (P. aeruginosa, ATCC 9027). ^cActivity levels; +++ ≥ 90%; ++ ≥ 70–89%; + ≥ 50–69%; − < 50%.