Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

<div>(a) Fluorescence microscopy analysis of cellular MMP level by JC-1 staining after Ru(II) complexes treatment for 12 h. (b) Flow cytometry analysis of cellular MMP level after Ru(II) complexes treatment for 12 h. (c) The quantification of green/red fluorescent intensity ratio by JC-1 staining after 5, 10, and 20 <i>μ</i>M of <b>Ru-1</b> and <b>Ru-2</b> treatment for 12 h. (d) The effect of <b>Ru-1</b> on the expression of Bcl-2 family proteins and cytochrome c in the cytosol.</div>

Bioinorganic Chemistry and Applications

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Figure 4

Figure 4: Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway 