Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Table 5

MIC of all active compounds.

Microbe	Li[Ru(Cl)4(DPA) (2) (mg/mL)	[Ru2(2BUT)(DMF)2(DPA)](BH4)4] (3) (mg/mL)	[Ru2(2BUT)(Cl)6] (4) (mg/mL)	2BUT (1) (mg/mL)	DPA (mg/mL)
S. aureus	5.00	1.88	7.50	0.03	15.00
MRSA	0	2.50	0	0	15.00
K. pneumoniae	10.00	7.50	10.00	20.00	1.88
MDR K. pneumoniae	0	0	0	0	0

Note: 0: not active. The compounds were assayed for their MIC towards S. aureus, K. pneumoniae, MRSA, and MDR K. pneumoniae. The assay revealed all complexes to display activity towards all non-drug-resistant bacteria. Only [Ru₂(2BUT)(DMF)₂(DPA)](BH₄)₄] complex displayed activity on MRSA together with the ligands. However, no compound indicated activity towards MDR K. pneumoniae. After this, the complexes were assayed for their bacterial growth inhibition using disc diffusion assay.