Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff’s Base of Acenaphthaquinone Transition Metal Complexes

Table 7

ABTS antioxidant assay and in vitro cytotoxicity against HepG2 cell line of the ligand and its complexes.

ABTS assay		In vitro cytotoxicity HePG2
Compounds	Inhibition %	Compounds	IC50 (µM)	SI
L-Ascorbic acid	88.8	Doxorubicin	4.50 ± 0.2	3.28
HAAT	88.4	HAAT	6.45 ± 0.25	1.14
Co(II) complex	65.3	Co(II) complex	67.31 ± 1.35	0.82
Ni(II) complex	81.4	Ni(II) complex	21.46 ± 0.72	0.93
Zn(II) complex	88.6	Zn(II) complex	6.39 ± 0.18	1.28

IC₅₀: 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and above 100 (noncytotoxic).