Synthesis, Characterization, and In Vitro Cytotoxicity of Unsymmetrical Tetradentate Schiff Base Cu(II) and Fe(III) Complexes

Table 1

In vitro cytotoxicity of the unsymmetrical tetradentate Schiff base Cu(II) complexes and Fe(III) complexes.

Compound	IC50 (µM)
	KB	Hep-G2
H2L1	>100	>100
[Cu(II)L1]	14.71 ± 0.11	21.04 ± 1.08
[Fe(III)L1Cl]	0.68 ± 0.05	0.83 ± 0.05
H2L2	>100	>100
[Cu(II)L2]	46.46 ± 2.42	18.05 ± 0.09
[Fe(III)L2Cl]	3.25 ± 0.16	7.05 ± 0.25
H2L3	80.49 ± 0.76	38.32 ± 1.28
[Cu(II)L3]	70.60 ± 3.29	35.99 ± 0.17
[Fe(III)L3Cl]	1.84 ± 0.10	6.07 ± 0.22
H2L4	>100	51.08 ± 2.42
[Cu(II)L4]	85.96 ± 4.57	50.52 ± 0.26
[Fe(III)L4Cl]	2.76 ± 0.17	19.78 ± 1.07
H2L5	>100	>100
[Cu(II)L5]	96.71 ± 5.11	>100
[Fe(III)L5Cl]	1.95 ± 0.13	2.38 ± 0.17
Ellipticine	1.14 ± 0.06	2.11 ± 0.12