Novel Synthesis of Titanium Oxide Nanoparticles: Biological Activity and Acute Toxicity Study

Figure 7

Photomicrograph of section of liver of control group (a) showing tightly packed cords of polygonal hepatocytes with rounded vesicular nuclei (black arrow), central vein (C) showing intact endothelial cells with flattened nuclei. Scattered irregular Kupffer cells with ovoid nuclei (red arrow). Low-dose treated group (b) showing mild affection of the hepatic lobule with preserved hepatic architecture. Hepatocytes arranged in cords radiating from dilated central vein and separated by blood sinusoids. However, high-dose treated group albino rat (c1) showed shrunken cells with hypereosinophilic cytoplasm and fragmented nuclei (black arrows) dilatation and cellular infiltration around the portal vessels and dilation and congestion in blood sinusoids (S), hepatocytes with vacuolar degeneration (red arrow) (c2). H & E staining 400x magnification.