Identification of Differentially Expressed Genes and Elucidation of Pathophysiological Relevance of ABCA1 in HaCaT Cells Induced by PM2.5

Figure 2

(a, b) 541 of 1476 DEGs were upregulated in HaCaT cells after PM2.5 stimuli, while 935 genes were downregulated. (c) Ingenuity canonical pathway analysis indicated inflammatory response-associated pathways are deregulated in PM2.5-treated HaCaT cells, like IL-10, IL-8, and NF-κB signaling. The differential genes of different treatment groups were selected by the IPA grid algorithm to select genes with noticeable downstream changes. (d) Gene network, showing the interaction between different treatment groups through the grid diagram relationship. (e) The regulatory effect network map shows the interaction between genes and regulators and functions in the dataset.

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