Recent Advances in the Development of Noble Metal NPs for Cancer Therapy

Table 2

Structure of platinum nanoparticles and indications in tumor therapy.

Types of drugs	Structural formula	Mechanism of action	Adaptive diseases	References
Tolfplatin (cisplatin)		A COX-2 inhibitor that suppresses the production of PEG2	Breast cancer	[72]
Carboplatin		A COX-2 inhibitor with amino-functionalized polyphosphazene vesicles	Carcinoma of ovary	[73]
Nedaplatin		A COX-2 inhibitor with higher plasma concentrations of 5-fluorouracil	Esophageal squamous cell carcinoma	[74]
Lipoxal (oxaliplatin)		An inhibitor of DNA synthesis that prevents DNA replication and transcription and causes cell death	Gastrointestinal cancers	[75]
Lobaplatin		Inhibit the proliferation of cancer cells and promote apoptosis	Small-cell carcinoma	[76]
Heptaplatin		An inhibitor of DNA synthesis that prevents DNA replication and transcription	Gastric cancer	[77]