Research Article
Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N4-Allylthiosemicarbazone
Table 4
IC50 values of HL thiosemicarbazone and complexes 1–6 toward MDCK, HL-60, HeLa, BxPC-3, and RD cell lines.
| | Compound | MDCK | HL-60 | HeLa | BxPC-3 | RD | | IC50, μM | IC50, μM | SIa | IC50, μM | SIa | IC50, μM | SIa | IC50, μM | SIa |
| | HL | >100 | 0.30 ± 0.02 | >300 | >100 | — | >100 | — | 1.10 ± 0.03 | >90 | | [Zn(H2O) (L)Cl] (1) | 38.5 ± 4.0 | 0.20 ± 0.03 | 193 | 1.4 ± 0.3 | 28 | 10.0 ± 0.3 | 3.9 | 0.06 ± 0.01 | 640 | | [Cu(L)Cl] (2) | 3.0 ± 0.4 | 0.10 ± 0.06 | 30 | 0.40 ± 0.03 | 7.5 | 0.05 ± 0.02 | 60 | 0.13 ± 0.02 | 23 | | [Cu(L)Br] (3) | 6.2 ± 1.4 | 0.10 ± 0.04 | 62 | 0.30 ± 0.03 | 21 | 0.06 ± 0.01 | 103 | 0.2 ± 0.1 | 31 | | [Cu2L2(CH3COO)2]·4H2O (4) | 2.0 ± 0.2 | 0.10 ± 0.02 | 20 | 0.20 ± 0.02 | 10 | 0.02 ± 0.01 | 100 | 0.05 ± 0.01 | 40 | | [Ni(HL)2]Cl2·H2O (5) | >100 | 0.09 ± 0.01 | >1000 | >100 | — | 3.6 ± 0.9 | >27 | 2.9 ± 0.4 | >34 | | [Co(L)2]Cl (6) | >100 | >10 | — | 2.5 ± 0.5 | >40 | 4.1 ± 0.5 | >24 | >100 | — | | Doxorubicin | 7.1 ± 0.3 | 0.2 ± 0.1 | 35.5 | 10.0 ± 0.4 | 0.71 | 3.7 ± 0.3 | 1.9 | 16.2 ± 0.6 | 0.44 |
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