Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N⁴-Allylthiosemicarbazone

Table 6

Antibacterial and antifungal activities of HL thiosemicarbazone and copper complexes 1–6 as MIC^a/MBC^b/MFC^c values (μg/mL).

Compound	S. aureus (G+)		E. coli (G-)		C. albicans
	MIC	MBC	MIC	MBC	MIC	MFC
HL	0.488	0.977	31.3	62.5	62.5	500
[Zn(H2O) (L)Cl] (1)	0.244	0.488	3.91	7.81	31.3	250
[Cu(L)Cl] (2)	0.122	0.244	3.91	7.81	15.6	31.3
[Cu(L)Br] (3)	0.244	0.488	7.81	15.6	7.81	15.6
[Cu2L2(CH3COO)2]·4H2O (4)	0.244	0.488	1.95	3.91	31.3	62.5
[Ni(HL)2]Cl2·H2O (5)	15.6	31.3	1000	—	500	—
[Co(L)2]Cl (6)	62.5	125	250	500	62.5	250
Furacillinum	9.3	9.3	18.5	37.5	—	—
Nystatin	—	—	—	—	80	80

S. aureus (Staphylococcus aureus, ATCC 25923); E. coli (Escherichia coli, ATCC 25922); C. albicans (Candida albicans, ATCC 10231). ^aMIC–minimum inhibitory concentration; ^bMBC—minimum bactericidal concentration; ^cMFC, minimum fungicidal concentration. G(-): Gram-negative bacteria; G(+): Gram-positive bacteria.