The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH<sub>3</sub>COO)Cl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

<div>A tentative scheme of the suggested mechanism of internalization of compound <b>2</b>.</div>

Bioinorganic Chemistry and Applications

fig10

Figure 10

Figure 10: The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH<sub>3</sub>COO)Cl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake 

Figure 10 | The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake 