Research Article
The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake
Figure 2
Accumulation ratio (AR) of cisplatin and 1–3 complexes in A2780 cells treated for 4 h at 37°C (gray bars) and 4°C (white bars) with 10 μM concentrations of the compounds. Data are the mean ± sd of three independent replicates and were compared using one-way analysis of variance (ANOVA) with the Tukey post-hoc test. Statistical analysis (cisplatin, 1, and 3 vs. 2, 37°C): < 0.001; (37°C vs. 4°C): < 0.01; < 0.001.