The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH₃COO)Cl₂(NH₃)₂(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

Figure 3

AR (gray bars, left axis scale) and DNA platination ( in pg Pt μg⁻¹ DNA, white bars, right axis scale) of cisplatin and Complexes 1–3 in A2780 cells after 24 h CT at 10 μM concentration. Data are the mean ± sd of three independent replicates and were compared using one-way analysis of variance (ANOVA) with the Tukey post-hoc test. Statistical analysis (AR, cisplatin, 1, and 3vs.2):  < 0.05,  < 0.001; (, cisplatin, 1, and 3vs.2):  < 0.001.