The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH₃COO)Cl₂(NH₃)₂(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

Figure 8

AR of cisplatin and 1–3 in A2780 (wild type; gray bars) and A2780cisR (cisplatin-resistant; white bars) cells after 4 h CT at a 10 μM concentration of compounds. Data are the mean ± SD of three independent replicates and were compared using one-way analysis of variance (ANOVA) with the Tukey post-hoc test. Statistical analysis (cisplatin, 1 and 3vs.2, A2780):  < 0.001; (cisplatin, 1 and 3vs.2, A2780cisR):  < 0.001.